Rams vs Seahawks Prediction, Picks & Best Bets for Thursday Night Football Week 16

Rams vs Seahawks prediction and best bet

Osborne's prediction: The Rams have dominated this matchup and are set to make a long night for Seahawks quarterback Sam Darnold.

The No. 1 seed in the NFC is up for grabs as the Los Angeles Rams and Seattle Seahawks collide in a marquee matchup tonight on Thursday Night Football.

My Rams vs. Seahawks predictions and NFL picks lean toward the visiting Rams, who bring a strong set of betting trends into the matchup.

Kickoff is set for 8:15 p.m. ET from Lumen Field in Seattle, with the game airing on Prime Video on December 18.

Why the Rams are the best bet

Rams vs Seahawks best bet: Rams -1 (-105)

I like backing betting trends, so it’s nearly impossible to overlook the Los Angeles Rams in this spot at a reasonable number.

Los Angeles has been one of the most reliable late-season bets in the NFL, compiling a 17–3 ATS record in their last 20 games played in the month of December. That trend has continued this year, with the Rams starting December 2–0 while piling up 86 total points against Arizona and Detroit, surpassing 500 yards of offense in both games. They’re peaking at the right time.

They’ve also dominated the spread in matchups against the Seattle Seahawks, covering 11 of the last 14 meetings, including five straight at Lumen Field. That level of consistency against a division opponent is hard to dismiss, particularly in a building that’s traditionally been difficult for visitors.

Road performance has also been a strength. Los Angeles has gone 11–2 ATS in its last 13 road games and owns a 17–5 ATS mark overall since December 1 of last season. Whether home or away, this team has shown an ability to travel and execute in high-leverage spots.

Even setting trends aside, there are reasons for skepticism on the Seattle side.

The Seahawks escaped with a narrow win over the Philip Rivers-led Colts last week despite being nearly two-touchdown favorites, and while they continue to accumulate wins, Sam Darnold’s play has cooled off. It’s also very fair to question his confidence in standalone, high-pressure games after he completely melted down at the end of last season with the Vikings.

That concern is amplified by the matchup itself. The Rams are 3–0 against Darnold since the start of last season and forced him into costly mistakes, including a four-interception performance just over a month ago.

Trends alone don’t decide games, but when form, matchup history, and quarterback results all point in the same direction, they deserve attention. On a short week in Seattle, the data suggests the Rams are once again positioned to continue their strong December run.

Same-game parlay angles for TNF

In addition to being 3-0 vs Darnold since the beginning of last season, Los Angeles has owned the Seahawks, going 11-3 ATS against them in the last 14 matchups.

Look for Kyren Williams to add to his 13 total TDs vs. a Seattle defense that's allowed the most receptions in the NFL to opposing running backs.

Rams vs Seahawks SGP (+593)

• Rams moneyline
• Kyren Williams anytime touchdown
• Kyren Williams Over 1.5 receptions

Big-ticket SGP: JSN as Seattle’s brightest spot

JSN has reached the 100-yard mark in an amazing eight of his last 10 games, including going for 105 vs. the Rams on November 15.

Los Angeles has allowed the sixth-most receiving yards to the wide receiver position this season.

Rams vs Seahawks SGP (+1207)

• Rams moneyline
• Kyren Williams anytime touchdown
• Kyren Williams Over 1.5 receptions
• Jaxon Smith-Njigba Over 95.5 receiving yards

Rams vs Seahawks game predictions

Moneyline prediction

The Rams have hit their stride during the stretch run of the season with back-to-back wins where they’ve dropped 40+ points and 500+ yards.

I’m not going to stand in front of that vs Darnold, who can’t be trusted in big spots like this.

Spread prediction

With the Rams being 17-3 ATS in their last 20 games played in December while also being 11-3 ATS in their last 14 games vs the Seahawks, I’ll happily side with them to cover.

Over/Under prediction

The Under also profiles well in a matchup between two of the league’s top defenses. These teams rank second and third in points allowed and played to a 21–19 game in November that was tracking even lower before late touchdowns.

Unless short fields or defensive scores swing the script, the metrics point toward a lower-scoring game.

Rams vs Seahawks odds

Key betting trend to know

The Rams are 17-3 ATS in their last 20 games played in December.

How to watch Rams vs Seahawks

Rams vs Seahawks injuries and weather

Latest injuries

Rosters and injury reports should be monitored leading up to kickoff for any late-breaking changes that could impact betting markets.

Weather outlook

Expect rain at Lumen Field tonight, with temps in the low 40s sliding toward the upper 30s. A wet night can make footing tricky and the ball harder to grip.

That usually shifts the edge toward the team that protects the ball and stays efficient: more runs, quick throws, fewer slow-developing deep shots. Missed tackles and fumbles tend to spike in the rain, and a slippery ball can also hurt field-goal consistency, so turnovers and special teams could decide it.