NFL DFS Picks: Week 12 Main Slate DraftKings Breakdown
The Week 12 DraftKings main slate features 12 games and several high-upside quarterback options. This breakdown focuses on how projections, trends, and game environments shape the top DFS decisions.
Using FantasyLabs tools and projections, the analysis highlights premium quarterback plays, value options, and quick-hit considerations for tournaments and cash games.
1.0
Default
Slate Overview and Tools
We have a 12-game slate in Week 11, with lock at the usual 1:00 p.m. ET.
In this article, various FantasyLabs tools and other industry metrics are used to break down the DFS slate.
Players can use the Lineup Builder if they like to hand-build their lineups or the Lineup Optimizer for entering multiple lineups into tournaments.
The SimLabs Lineup Generator gives users the ability to create advanced DFS lineups using the power of simulation.
An in-depth SimLabs guide is also available for those who want to better understand how to leverage simulations in lineup construction.
Projections are available for purchase within the FantasyLabs Models, with Chris Raybon’s projections included with a FantasyLabs subscription. Projections from One Week Season and Establish the Run are also available for subscribers to those specific sites, with the optimizer offered as a separate add-on feature.
Users can combine multiple projection sources to create their own aggregate projections.
NFL DFS Quarterback Picks
Stud: Drake Maye ($6,900) New England Patriots (-7) at Cincinnati Bengals (51.5 Total)
With Josh Allen off the Week 12 main slate, Josh Allen Jr., AKA Drake Maye, holds down the top spot in the projections. Maye’s salary has risen to the point where his typical mid-20s DraftKings score probably will not win a tournament, but he is in an elite spot this week that gives him an excellent chance to score well above his typical range.
The MVP candidate can get it done through the air or with his legs, with 20 passing touchdowns plus 285 rushing yards and two scores on the ground. New England has been one of the top Pass Rate Over Expectation (PROE) teams in the league this season, ranking sixth — right behind the Bengals at fifth.
The Bengals are both an aggressive offense and the NFL’s worst defense, which makes for an elite combination for opposing offenses. This game should be fast, and the Patriots should be extremely efficient. While New England is favored by seven at the moment, there are also rumors that Joe Burrow will be back for the Bengals, which likely pushes the total up and the spread tighter if he returns.
With this game already featuring the highest total on the board, Burrow’s return would push it into elite territory. That might be the deciding factor on whether to roster Maye heavily this week.
Value: Jacoby Brissett ($5,300) Arizona Cardinals (+3) vs. Jacksonville Jaguars (47.5 Total)
There have now been five weeks of Jacoby Brissett starting for the Cardinals and five games with at least 20 DraftKings points. That was especially impressive last week, when he was able to get there without number one wide receiver Marvin Harrison — and it is a reassuring sign now that Harrison has been ruled out for Week 12 as well.
A Brissett triple stack took down the Millionaire Maker last week, and he is still priced at just $5,300. At the rate things are going, by the time Brissett’s salary rises to the point that rostering him is a tough decision, Kyler Murray will likely be back for the Cardinals. Either way, he is far too cheap for a matchup with the Jaguars, who rank 27th in points allowed to quarterbacks.
“Slight home underdog” might also be the sweet spot for quarterback production, with the Trends Tool showing that they outperform expectation when the game total is at least 45.
Plus, a thin running back room has led to the Cardinals being one of the pass-heaviest teams in recent weeks, ranking fourth in PROE since Week 10, and Brissett attempting 40 or more passes in three of his five starts. That gives him a volume-based floor at worst, making him a cash-game lock. He is the clear leader in points-per-salary projection.
Quick-Hit Quarterback Options
Patrick Mahomes ($6,800) is tied with Maye for the best median projection on the slate, with a slightly lower ceiling. He and the Chiefs have shifted to a more pass-centric approach since getting healthy at wide receiver and now have a potential shootout on their hands with the fast-paced Colts. Mahomes has struggled the past two weeks in road games against the Bills and Broncos, but a home game against the Colts might be the perfect spot to get back on track.
Jalen Hurts ($6,600) and the Eagles offense had little to do with their Sunday Night Football win over the Lions, who were even able to stop the “tush push” on multiple occasions. They have a drastically different matchup this week against the Cowboys’ 31st-ranked defense. The Eagles offense has struggled most of the season, but there is no better get-right spot than Dallas, making this a solid buy-low opportunity.
Jared Goff ($6,000) completed just 14 of 37 pass attempts against the Eagles last week, but that was outdoors against a tough defense. He is back at home against the Giants, where his notorious indoor/outdoor splits are in his favor. The one downside might be that the Lions could run the ball all over the Giants and make the passing attack an afterthought. However, the loss of Sam LaPorta makes the passing offense more concentrated, so there is still a case for some exposure to Goff stacks. He and the Lions have the slate’s highest team total.
NFL DFS Running Back Picks
The original article content transitions at this point into running back picks and additional positions, but that portion is not fully included in the extracted text. The focus here remains on the quarterback analysis and the tools and trends that support those DFS decisions.