NFL Week 12 Betting Guide: Picks, Predictions and Odds for Every Game
Week 12 of the 2025 NFL season kicks off Thursday night when the Buffalo Bills visit the Houston Texans and wraps up Monday with Christian McCaffrey and the San Francisco 49ers facing his former team, the Carolina Panthers. With no international games on the slate, Sunday’s action starts at 1 p.m. ET and features several key divisional showdowns.
USA TODAY’s panel of NFL experts has locked in its picks and predictions for every Week 12 matchup, alongside live odds and updated Super Bowl 60 futures to help bettors navigate the full schedule.
⏳ 5 mins read
📖 Published: November 20th, 2025
✍️ Updated: November 20th, 2025
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NFL Week 12: Picks, predictions and odds for every game
USA TODAY
Week 12 of the 2025 NFL season kicks off on Thursday night when the Buffalo Bills visit the Houston Texans and wraps up Monday night with Christian McCaffrey's San Francisco 49ers facing off against the tailback's former franchise, the Carolina Panthers.
There are no international games this week, which means the Sunday slate will kick off at 1 p.m. ET with two stellar divisional matchups. The Minnesota Vikings head to Wisconsin to face the Green Bay Packers followed by the Dallas Cowboys welcoming the Philadelphia Eagles to Texas.
USA TODAY's panel of NFL experts have locked in their picks and predictions for all the action. Here's everything you need to know for every Week 12 matchup.
Expert records through Week 10
| Name | Week 10 | 2025 Season |
|---|---|---|
| Jon Hoefling | 7-8 | 84-77-3 |
| Blake Schuster | 11-4 | 83-65-3 |
| Tyler Dragon | 6-9 | 82-79-3 |
| Chris Bumbaca | 11-4 | 78-83-3 |
| Lorenzo Reyes | 6-9 | 77-86-3 |
| Jordan Mendoza | 7-8 | 64-68-2 |
| Richard Morin | N/A | 25-12-1 |
NFL Week 12 picks, predictions, odds
- Bills at Texans
- Seahawks at Titans
- Giants at Lions
- Jets at Ravens
- Steelers at Bears
- Patriots at Bengals
- Colts at Chiefs
- Vikings at Packers
- Browns at Raiders
- Jaguars at Cardinals
- Falcons at Saints
- Eagles at Cowboys
- Buccaneers at Rams
- Panthers at 49ers
NFL Week 12 live odds
Get the edge with our exclusive NFL betting picks
Super Bowl 60 updated odds
This schedule was generated automatically using information from Stats Perform and a template written and reviewed by a USA TODAY Sports editor. You can send feedback using this form.
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