2025 NFL Week 13 Predictions, Betting Odds & TV Schedule
Week 13 of the 2025 NFL season features a full slate of games, highlighted by key matchups such as the Houston Texans visiting the Indianapolis Colts. Bettors have a complete board of spreads, moneylines and totals to consider.
Below are the betting odds, score predictions and TV details for every Week 13 matchup, including national broadcasts and streaming options.
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Week 13 Betting Lines & Game Info
There is a lot to be excited about on the Week 13 NFL schedule, including the Houston Texans taking on the Indianapolis Colts.
Here are the betting odds to dissect ahead of Week 13 in the NFL.
Detroit Lions vs. Green Bay Packers
Odds & Prediction
- Spread: Lions (-2.5)
- Moneyline: Lions -145, Packers +122
- Total: 49 points
- Prediction: Lions 26, Packers 21
How to Watch
Game Date: Thursday, Nov. 27
Game Time: 1 p.m. ET
TV Channel: FOX
Location: Detroit, Michigan
Dallas Cowboys vs. Kansas City Chiefs
Odds & Prediction
- Spread: Chiefs (-3)
- Moneyline: Chiefs -180, Cowboys +149
- Total: 52 points
- Prediction: Chiefs 27, Cowboys 23
How to Watch
Game Date: Thursday, Nov. 27
Game Time: 4:30 p.m. ET
TV Channel: CBS
Location: Arlington, Texas
Baltimore Ravens vs. Cincinnati Bengals
Odds & Prediction
- Spread: Ravens (-7)
- Moneyline: Ravens -339, Bengals +272
- Total: 51.5 points
- Prediction: Ravens 34, Bengals 18
How to Watch
Game Date: Thursday, Nov. 27
Game Time: 8:20 p.m. ET
TV Channel: NBC/Peacock
Location: Baltimore, Maryland
Philadelphia Eagles vs. Chicago Bears
Odds & Prediction
- Spread: Eagles (-6.5)
- Moneyline: Eagles -326, Bears +261
- Total: 44.5 points
- Prediction: Eagles 29, Bears 19
How to Watch
Game Date: Friday, Nov. 28
Game Time: 3 p.m. ET
TV Channel: Amazon Prime Video
Location: Philadelphia, Pennsylvania
Tampa Bay Buccaneers vs. Arizona Cardinals
Odds & Prediction
- Spread: Buccaneers (-3)
- Moneyline: Buccaneers -161, Cardinals +135
- Total: 44.5 points
- Prediction: Buccaneers 30, Cardinals 19
How to Watch
Game Date: Sunday, Nov. 30
Game Time: 1 p.m. ET
TV Channel: FOX
Location: Tampa, Florida
Cleveland Browns vs. San Francisco 49ers
Odds & Prediction
- Spread: 49ers (-5)
- Moneyline: 49ers -237, Browns +194
- Total: 38 points
- Prediction: 49ers 27, Browns 15
How to Watch
Game Date: Sunday, Nov. 30
Game Time: 1 p.m. ET
TV Channel: CBS
Location: Cleveland, Ohio
Miami Dolphins vs. New Orleans Saints
Odds & Prediction
- Spread: Dolphins (-6)
- Moneyline: Dolphins -275, Saints +224
- Total: 41.5 points
- Prediction: Dolphins 24, Saints 19
How to Watch
Game Date: Sunday, Nov. 30
Game Time: 1 p.m. ET
TV Channel: FOX
Location: Miami Gardens, Florida
Indianapolis Colts vs. Houston Texans
Odds & Prediction
- Spread: Colts (-4.5)
- Moneyline: Colts -223, Texans +185
- Total: 44.5 points
- Prediction: Colts 24, Texans 21
How to Watch
Game Date: Sunday, Nov. 30
Game Time: 1 p.m. ET
TV Channel: CBS
Location: Indianapolis, Indiana
Carolina Panthers vs. Los Angeles Rams
Odds & Prediction
- Spread: Rams (-10.5)
- Moneyline: Rams -649, Panthers +471
- Total: 45 points
- Prediction: Rams 31, Panthers 12
How to Watch
Game Date: Sunday, Nov. 30
Game Time: 1 p.m. ET
TV Channel: FOX
Location: Charlotte, North Carolina
Tennessee Titans vs. Jacksonville Jaguars
Odds & Prediction
- Spread: Jaguars (-6.5)
- Moneyline: Jaguars -312, Titans +253
- Total: 41.5 points
- Prediction: Jaguars 27, Titans 18
How to Watch
Game Date: Sunday, Nov. 30
Game Time: 1 p.m. ET
TV Channel: CBS
Location: Nashville, Tennessee
New York Jets vs. Atlanta Falcons
Odds & Prediction
- Spread: Falcons (-2.5)
- Moneyline: Falcons -145, Jets +122
- Total: 39.5 points
- Prediction: Falcons 24, Jets 20
How to Watch
Game Date: Sunday, Nov. 30
Game Time: 1 p.m. ET
TV Channel: FOX
Location: East Rutherford, New Jersey
Seattle Seahawks vs. Minnesota Vikings
Odds & Prediction
- Spread: Seahawks (-10.5)
- Moneyline: Seahawks -637, Vikings +464
- Total: 41.5 points
- Prediction: Seahawks 33, Vikings 14
How to Watch
Game Date: Sunday, Nov. 30
Game Time: 4:05 p.m. ET
TV Channel: FOX
Location: Seattle, Washington
Pittsburgh Steelers vs. Buffalo Bills
Odds & Prediction
- Spread: Bills (-3.5)
- Moneyline: Bills -201, Steelers +166
- Total: 47.5 points
- Prediction: Bills 26, Steelers 24
How to Watch
Game Date: Sunday, Nov. 30
Game Time: 4:25 p.m. ET
TV Channel: CBS
Location: Pittsburgh, Pennsylvania
Los Angeles Chargers vs. Las Vegas Raiders
Odds & Prediction
- Spread: Chargers (-9.5)
- Moneyline: Chargers -592, Raiders +427
- Total: 41 points
- Prediction: Chargers 28, Raiders 14
How to Watch
Game Date: Sunday, Nov. 30
Game Time: 4:25 p.m. ET
TV Channel: CBS
Location: Inglewood, California
Washington Commanders vs. Denver Broncos
Odds & Prediction
- Spread: Broncos (-6.5)
- Moneyline: Broncos -324, Commanders +259
- Total: 43.5 points
- Prediction: Broncos 28, Commanders 17
How to Watch
Game Date: Sunday, Nov. 30
Game Time: 8:20 p.m. ET
TV Channel: NBC/Peacock
Location: Landover, Maryland
New England Patriots vs. New York Giants
Odds & Prediction
- Spread: Patriots (-7.5)
- Moneyline: Patriots -413, Giants +322
- Total: 46.5 points
- Prediction: Patriots 30, Giants 18
How to Watch
Game Date: Monday, Dec. 1
Game Time: 8:15 p.m. ET
TV Channel: ESPN
Location: Foxborough, Massachusetts